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Curcumin

Curcumin is the primary bioactive substance in turmeric. It has anti-inflammatory properties, and there is decent evidence that it can alleviate various conditions, from chronic pain to depression. For ages, curcumin has been used by mankind to treat chronic and serious medical conditions like inflammatory bowel disease (IBS), rheumatoid arthritis, Crohn’s disease, Alzheimer’s disease (AD), vitiligo, psoriasis, gastric and peptic ulcers, and many cancers. Curcumin is a potent photosensitizer for PDT in the treatment of psoriasis, tumors, infections and other diseases. Even in low concentrations curcumin acts phototoxic (to bacteria), proapoptotic, anti-inflammatory, immune stimulating, radioprotective, chemoprotective, antitumoral, antimetastatic, anti-angiogenetic, radio-sensitizing and chemo-sensitizing.

Artesunate

Extracts of the medicinal plant Artemisia annua L. (Annual Wormwood) have been used in traditional Chinese medicine for more than two thousand years. In the 1970s, the active substance artemisinin was identified and clinically characterized as an effective antimalarial drug. In several international studies the natural active ingredient artemisinin has been shown to have strong cytostatic effects on cancer cells.

Hypericin

Hypericin has been an integral part of naturopathy and empirical medicine for centuries and has been sufficiently proven and documented with regard to its effect, especially in the oral area, on mild to moderate depression. Nervousness, sleep disorders, depressed mood and neurovegetative symptoms, which often occur in connection with depression, can also be improved. With the help of high-dose hypericin (St. John’s wort) infusions, however, St. John’s wort is now also playing an increasingly important role in biological cancer therapy. It is also a powerful naturally occurring photosensitizer used in photodynamic therapy (PDT) for the treatment of cancer.

Riboflavin

Also known as the “growth vitamin,” vitamin B2 is a water-soluble B vitamin. It exists both as inactive, unbound riboflavin, as a protein-bound form, and in two bioactive coenzyme forms: Flavin mononucleotide (FMN), also known as riboflavin 5′-phosphate (R5P), or as flavin adenine dinucleotide (FAD). Both are important enzyme cofactors that regulate numerous metabolic processes and play a key role in many bodily functions: including energy production, growth, embryonic development, and the protection of nerve cells. Riboflavin selectively binds to DNA and can be photo-excited with low energy visible light of long wavelength light as it has an absorption peak at 447nm. In anti-microbial PDT Riboflavin is used to treat viral, bacterial and parasitic diseases. When activated by light it deactivates pathogens in the blood.

Resveratrol

Resveratrol can prevent the formation of cancer cells by preventing damage to our genes (DNA). If cancer cells already exist, resveratrol activates a self-destruction mechanism that leads to cell death. Malignant cells produce specific inflammatory markers that promote further growth and spread of cancer cells. Resveratrol inhibits the production of these markers at the genetic level and blocks further inflammation amplification.

Q10

Coenzyme Q10 plays a central role in mitochondrial oxidative phosphorylation and the production of adenosine triphosphate (ATP). It also functions as an antioxidant in cell membranes and lipoproteins.

Boswellia

The major component is boswellic acid, a 5-lipoxygenase inhibitor with anti-inflammatory and anti-arthritic effects. It also demonstrated cytotoxic and radio-enhancing properties and has shown inhibition of tumor cell growth. Boswellia acids trigger apoptosis by activating the caspase-8 pathway and suppressing the anti-apoptotic transcription factor NF-kB. AKBA also inhibits topoisomerase, which is responsible for inhibiting apoptosis.

Oliphenolia

OLIPHENOLIAO® is the first product in the world to be based on olive-mill water from cold-pressed olives – „acqua mora” – in injection form. The basis of OLIPHENOLIA® i.v. is a liquid phytocomplex consisting of a natural mixture of the polyphenols gained from olives (hydroxytyrosol, oleuropein aglycone, tyrosol, verbascosides, chlorogenic acid, secologanosides alongside many others). By way of comparison, the concentration is 20 times higher than in extra virgin olive oil.

Epigallocatechin gallate (EGCG)

EGCG is the ester of epigallocatechin and gallic acid, and is a type of catechin. Catechins belong to the group of polyphenols. Polyphenols share various therapeutic effects against pathological conditions including cancer, inflammation, diabetes, and cardiovascular diseases. EGCG has been proven to have multiple effects on human pathological and physiological processes and its mechanisms are discrepant in cancer, vascularity, bone regeneration and nervous system.

Shogaol

Ginger – with its active ingredient shogaol – may have anti-cancer properties due to a cytotoxic effect on tumor stem cells, which are responsible for growth, resistance and metastasis. It stops mitosis (inhibits cell multiplication, tiggers apoptosis and has autophagy effects by inhibiting AKT/mTOR pathways). Based on studies, this has already been concretely demonstrated in breast and colon cancer cells. In addition, further study results show that ginger could be a promising agent in the context of cancer therapies.

DCA

DCA has an effect on blocked or altered mitochondria in the cells. If there is a disturbance in mitochondrial metabolism, DCA can completely reverse this disturbance and thus restore normal energy production. For decades, the active ingredient DCA has therefore been used to treat congenital mitochondrial dysfunctions or mitochondrio- pathies (genetic metabolic disorders). The potential efficacy of DCA in cancer therapy comes from metabolic properties of cancer cells, typically characterized by increased glycolytic activity and reduced mitochondrial oxidation.

NAD+

The molecule has two forms – one active and one inactive. In its active form it is known as NAD+ and in its inactive form as NADH. It plays a role in converting food into energy, maintaining DNA integrity, and ensuring proper cellular function and repair. Yet humans only have the ideal level of NAD+ at birth, which we need as a particularly important coenzyme to fuel the body‘s metabolic activity and hence energy production. As we age, the level of NAD+ in our bodies naturally declines. This leads to our mitochondria being undersupplied, which impairs the way they function and results in dying cells, and we age. This explains why damage to our genetic makeup is less and less likely to be corrected at an advanced age and why, in turn, many types of disease can develop.

Mistletoe

Up to 77% of cancer patients trust in the effect of mistletoe therapy, which usually means that they tolerate their cancer treatment better and improve their quality of life. Mistletoe therapy achieves this effect by, among other things, strengthening the immune system, reducing fatigue and normalizing mood, sleep and the sensation of warmth.